In my humble opinion, the most memorable season opener in Michigan football history happened on August 26, 1995. It was Lloyd Carr's first game as the head coach.
Michigan had slept thru the first three quarters of the game. With 12:55 to go, the Wolverines trailed 17th-ranked Virginia 17-0. Then the comeback began. We scored on a pair of drives to cut the deficit to 17-12, then got the ball back again, on the 20 yard line with 2:35 left. Somehow we kept making first downs. Time was running out. With four seconds remaining, freshman WR Tyrone Butterfield (wearing the #1 jersey) dropped a pass that would have run the clock out and sealed the victory for Virginia. But no... there was time for one more play.... and Mercury Hayes made a game-winning, fourth down, as time expired 15-yard touchdown catch from Scott Dreisbach to seal an 18–17 win in Michigan's greatest (at the time) comeback.
HT: 616goblue for reminding me of this great image captured by Erik Campos of the Grand Rapids Press and picked up by Sports Illustrated.
YouTube Highlights of this game HERE